The Garnis Lab » Publications

New Garnis Lab Publication!

admin — Fri, 27 Jan 2012 20:47:15 +0000

Gorenchtein M, Poh CF, Saini R, Garnis C (2011). MicroRNAs in an Oral Cancer Context – from Basic Biology to Clinical Utility, J Dent Res, 91(5):440-6.

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BRF2 is a lineage-specific marker for lung squamous cell carcinoma and is increasingly activated during lung cancer progression

admin — Thu, 29 Jul 2010 17:04:59 +0000

A new paper in PLoS Medicine identifies BRF2 as an oncogene specific to lung squamous cell carcinoma, providing a marker to distinguish between subgroups of non-small cell lung cancer. Moreover, work in this paper shows how BRF2 is increasingly activated as disease progresses from premalignant stages to invasive cancer. Dr. Garnis contributed to this broad work, spearheaded by Dr. Will Lockwood.

Parallel molecular analysis of different disease stages – and different histological subgroups of disease – is yielding important insights into the mechanisms that drive cancer initiation and progression. Ultimately, genes like BRF2 may become targets for the next generation of therapies that are tailored against individual tumors.

Lockwood WW, Chari R, Coe BP, Thu KL, Garnis C, Malloff CA, Campbell J, Williams AC, Hwang D, Zhu CQ, Buys TPH, Yee J, English JC, MacAulay C, Tsao MS, Gazdar AF, Minna JD, Lam S, Lam WL. (2010) Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma. PLoS Med 7(7): e1000315. (link)

A new review on integrating multidimensional molecular data

admin — Thu, 04 Feb 2010 01:18:08 +0000

Dr. Garnis recently contributed to a review article entitled “Integrating the multiple dimensions of genomic and epigenomic landscapes of cancer”. Raj Chari was the lead author and the piece was published at Cancer and Metastasis Reviews.

Large genomic, epigenomic, and gene expression datasets are now mainstays of molecular research. Analytical approaches to integrating these data are steadily improving. This review describes the state of work in this area and also delves into the high throughput functional tools that are available for validating results from integrated analysis.

(link, link)

New Garnis Lab Publication (#4)

admin — Fri, 18 Dec 2009 18:21:11 +0000

Tsui IF, Garnis C (2010) Integrative molecular characterization of head and neck cancer cell model genomes, Head & Neck, 32(9):1143-60.

(link, link)

New Garnis Lab Publication (#3)

admin — Fri, 30 Oct 2009 21:38:25 +0000

Tsui IF, Garnis C, Poh CF (2009) A dynamic oral cancer field: unraveling the underlying biology and its clinical implication, American Journal of Surgical Pathology 33(11):1732-8.

(link, link)

New Garnis Lab Publication (#2)

admin — Mon, 27 Jul 2009 11:24:23 +0000

Garnis C, Chari R, Buys TPH, Zhang L, Ng RT, Rosin MP, Lam WL (2009) Genomic imbalances in precancerous tissues signal oral cancer risk, Molecular Cancer (epub)

(link)

New Garnis Lab publication (#1)

admin — Fri, 24 Jul 2009 11:18:03 +0000

Tsui IF, Poh CF, Garnis C, Rosin MP, Zhang L, Lam WL (2009) Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias, International Journal of Cancer (epub, ahead of print).

link

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